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劉棋銘

劉棋銘｜Liu, Chi-Ming   劉棋銘｜Liu, Chi-Ming
🎓   助理教授
👨‍🎓   高雄醫學大學
       醫學研究所博士
📞　07-7811151 轉 7038
📧　ZO698@fy.edu.tw
📖　學術專長
藥理學、美容醫學、美容活性成分研究、抗氧化成分開發
學歷
  • 高雄醫學大學藥學系學士
  • 高雄醫學大學醫學研究所博士
學術專長
  • 藥理學
  • 美容醫學
  • 美容活性成分研究
  • 抗氧化成分開發
經歷
  • 宜春學院醫學院藥理教研室內聘副教授
  • 慈惠醫護管理專科學校護理科助理教授兼組長
  • 劉琳榕小兒科診所小兒科診所藥師
  • 臺灣汎生製藥廠股份有限公司研發部研發專員
  • 長庚醫院生物醫學轉譯研究中心博士後研究員
證照
  • 行政院衛生署藥師證書
專題指導
  • 2026年碩士論文: 吡非尼酮下調Ⅰ類HDACs並抑制TGF-β/Smad通路改善雄激素誘導的小鼠前列腺增生,蔡佳藝 (宜春學院)
  • 2025年碩士論文: 一種α葡萄糖苷酶抑制劑-肉桂素抗前列縣增殖藥理機制探索,韓滌 (宜春學院)
  • 2024年碩士論文: 辣椒素調控RAGE/IGF-1/AKT信號通路和抑制上皮細胞間質轉化抗糖尿病前列腺增生,孫慧 (宜春學院)
  • 2024年碩士論文: 多沙唑嗪調控EMT和TGF-β信號通路抑制雄激素誘導前列腺增生和纖維化,李一丹 (宜春學院)
  • 2023年碩士論文: Sinularin抗前列腺癌及癌轉移機制研究,蘇夢俏
  • 2023年碩士論文:甲基蓮心鹼下調雄激素介導上皮間質轉化作用抗良性前列腺增生機制研究, 邵子辰 (宜春學院)
  • 2022年碩士論文：6-薑酚調控LPS介導前列腺癌細胞生長與上皮細胞間質轉化機制研究,安麗杰 (宜春學院)
研期刊論文
  1.  Han D, Chen CY, Huang X, Liu Y, Sun H, Li Yi, Liao M, Cai J, Liu J, Li W, Zhang P, Wu Z, Liu CM* Cinnamophilin ameliorates testosterone-induced prostatic hyperplasia and fibrosis by regulating 5α-reductase and TGF-β/ Smad signaling pathway. Iran. J. Basic Med. Sci. 29(1), 121–127 (2026) (Impact factor:2.7 Ranking: Q2 164/352) (通訊作者)
  2. Wu Z, Cai J, Li N, Han D, Liu H, Mai X, Chen S, Liao M, Zhang P, Liu CM* Wharton’s jelly-mesenchymal stem cells alleviate atopic dermatitis by regulating TXNIP/NLRP3 and HDAC3/TGF‐β1 signaling pathway in mice. Rev Romana Med Lab. 33(4), 241–250 (2025) (Impact factor:0.5 Ranking: Q4 180/195) (通訊作者)
  3. Chen CY*, Liu CM, Yeh HC, Li WJ, Li HT*. Secondary Metabolites of Ficus benjamina. Chem Nat Compd 61, 381–382 (2025). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  4. Chen CY*, Cheng MJ, Liu CM. Huang ST, Li WJ, Li HT*. Lignans of Cinnamomum tenuifolium and Coix lachrymal-jobi. Chem Nat Compd 61, 22–26 (2025). (Impact factor:0.8 Ranking: Q4 47/58) (第三作者)
  5. Chen CY*, Liu CM, Cheng MJ, Yeh HC, Li WJ, Li HT*. Secondary Metabolites of Ficus religiosa. Chem Nat Compd 61, 68–71 (2025). (Impact factor:0.8 Ranking: Q4 47/58)  (第二作者)
  6. Chen CY*, Cheng MJ, Liu CM, Li WJ, Li HT*. A New Furan of Synsepalum dulcificum. Chem Nat Compd. 61, 83–85 (2025). (Impact factor:0.8 Ranking: Q4 47/58) (第三作者)
  7. Li Y, Tu B, Wang Z, Shao Z, Fu C, Hua J, Zhang Z, Zhang P, Sun H, Mao C, Liu CM*. Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-mesenchymal Transition in Mice and Stroma Cells. Curr Mol Pharmacol. 17(1), e18761429315125. (2025) (Impact factor:2.4 Ranking: Q3 188/354) (通訊作者)
  8. Sun H, Wang Z, Tu B, Shao Z, Li Y, Han D, Jiang Y, Zhang P, Zhang W, Wu Y, Wu X, Liu CM*. Capsaicin Reduces lood glucose and prevents prostate growth by regulating androgen, RAGE/IGF‑1/Akt, TGF‑β/Smad signalling pathway and reversing epithelial‑mesenchymal transition in streptozotocin‑induced diabetic mice. Naunyn Schmiedebergs Arch Pharmacol. 397(10), 7659-7671 (2024). (Impact factor:3.1 Ranking: Q2 126/354) (通訊作者)
  9. Chen CY*; Liu CM; Yeh HC, Li WJ, Liu SL*, Chuang CH*, Lee CH*, Hsu JL*. Metabolites from Cinnamomum subavenium with anti-dengue virus activity. Chem Nat Compd. 60, 153–156 (2024). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  10. Wang SJ, Liu CM, Li WJ, Yeh HC, Li HT*, Chen CY*. A new ionone compound from Liriodendron tulipifera. Chem Nat Compd. 60, 629–631 (2024). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  11. Liu CM*#, Shao Z#, Chen X, Chen H, Su M, Zhang Z, Wu Z, Zhang P, An L, Jiang Y, Ouyang AJ. Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways. Saudi Pharm J. 31(7), 1219-1228 (2023). (Impact factor:4.1 Ranking: Q2 136/354) (通訊兼共同第一作者)
  12. Wu Z#, Su M#, Chen H, Chen X, Chen CY, An L, Shao Z, Liu X, Lin Y, OuYang AJ, Liu CM*. Sinularin exerts anti-cancer effects by inducing oxidative stress-mediated ferroptosis, apoptosis, and autophagy in prostate cancer cells. Anti-cancer Agents Med Chem. 23(12), 1457-1468 (2023) (Impact factor:2.8 Ranking: Q3 168/241) (通訊作者)
  13. Shao Z, Chen CY, Chen X, Chen H, Su M, Sun H, Li Y, Tu B, Wang Z, Liu CM*. Capsaicin exerts anti-benign prostatic hyperplasia effects via inhibiting androgen receptor signaling pathway. BIOCELL. 47(6), 1389 (2023). (Impact factor:1.2 Ranking: Q4 73/92) (通訊作者)
  14. Chen CY*, Hsu LY, Liu CM, Huang ST, Li WJ, Li HT*. A new homosesquiterpene from Cinnamomum reticulatum. Chem Nat Compd. 59(2), 282–284 (2023). (Impact factor:0.8 Ranking: Q4 47/58) (第三作者)
  15. Chen CY*, Liu CM, Yeh HC, Li WJ, Li HT, Cheng MJ*. New metabolite from Cinnamomum tenuifolium. Chem Nat Compd. 59(2), 336–338 (2023). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  16. Chen CY*, Liu CM, Yeh HC, Li WJ, Li HT*, Chuang CH*. Anti-dengue virus activity of Michelia pilifera. Chem Nat Compd. 59(1), 201–203 (2023). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  17. Chen CY*, Liu CM, Yeh HC, Li WJ, Li HT*, Chuang CH*. Metabolites from Alpinia zerumbet with anti-dengue virus activity. Chem Nat Compd. 59(2), 367–370 (2023). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  18. Chen CY*, Liu CM, Yeh HC, Li WJ, Li HT*, Chuang CH*. Anti-covid-19 activity compounds from Michelia crassipes. Chem Nat Compd. 59(2), 371–373 (2023). (Impact factor:0.8 Ranking: Q4 47/58) (第二作者)
  19. Liu CM*#, An L#, Wu Z, Ouyang AJ, Su M, Shao Z, Lin Y, Liu X, Jiang Y. 6‑Gingerol suppresses cell viability, migration and invasion via inhibiting EMT, and inducing autophagy and ferroptosis in LPS‑stimulated and LPS‑unstimulated prostate cancer cells. Oncol Lett. 23(6), 187 (2022) (Impact factor:3.11 Ranking: Q3 176/245) (通訊兼共同第一作者)
  20. Liu CM, Yeh HC, Li WJ, Wang YC, Li HT*, Wang HM*, Chen CY*. Cytotoxic constituents of Michelia alba. Chem Nat Compd. 58(4), 773–776 (2022). (Impact factor:0.83 Ranking: Q4 50/56) (第一作者)
  21. Shao Z, Zhu B, Huang A, Su M, An L, Wu Z, Jiang Y, Guo H, Han XQ, Liu CM*. Docosahexaenoic acid reverses epithelial-mesenchymal transition and drug resistance by impairing the PI3K/AKT/Nrf2/GPX4 signalling pathway in docetaxel-resistant PC3 prostate cancer cell. Folia Biologica. 68, 59-71 (2022) (Impact factor:1.167 Ranking: Q4 77/94) (通訊作者)
  22. Chen CY *, Liu CM, Yeh HC, Li WJ, Li HT*, Cheng MJ, Su I, Wang HM*, Chiou YL*. Antioxidant and anticancer aromatic compounds of Zingiber officinale. Chem Nat Compd. 58(4), 751–753 (2022). (Impact factor:0.83 Ranking: Q4 50/56) (第二作者)
  23. Chen CY *, Liu CM, Yeh HC, Li WJ, Li HT*, Cheng MJ. A new β-ionone from Epimedium sagittatum. Chem Nat Compd. 58(5), 830–832 (2022). (Impact factor:0.83 Ranking: Q4 50/56) (第二作者)
  24. Chen CY *, Liu CM, Yeh HC, Li WJ, Li HT*, Cheng MJ, Hsieh PC*, Wang HM*. A new β-ionone from Liriodendron tulipifera. Chem Nat Compd. 58(3), 455–458 (2022). (Impact factor:0.83 Ranking: Q4 50/56) (第二作者)
  25. Liu CM*#, Wu Z#, Pan B, An L, Zhu C, Zhou J, Jiang Y. The antiandrogenic effect of neferine, liensinine, and isoliensinine by inhibiting 5-α-reductase and androgen receptor expression via PI3K/AKT signaling pathway in prostate cancer. Pharmazie. 76(5), 225-231 (2021). (Impact factor:1.267 Ranking: Q4 140/178) (通訊兼共同第一作者)
  26. Liu CM, Yeh HC, Wu HM, Li WJ, Li HT*, Chuang CH*, CH CY*. Flavonoids of Morus alba. Chem Nat Compd. 57(7), 1119–1121 (2021). (Impact factor:0.809 Ranking: Q4 52/63) (第一作者)
  27. Chen CY*, Liu CM, Yeh HC, Wu HM, Li WJ, Li HT*. Flavonoids of Crithmum maritimum. Chem Nat Compd. 57(5), 917–920 (2021). (Impact factor:0.809 Ranking: Q4 52/63) (第二作者)
  28. Chen CY*, Liu CM, Wu HM, Yeh HC, Li WJ, Li HT, Chang HW*. A New pyrone from Cinnamomum macrostemon. Chem Nat Compd. 56(4), 621–622 (2020). (Impact factor:0.653 Ranking: Q4 52/57) (第二作者)
  29. Wu Z#, Chen CY#, Kao CL, Jiang Y, Liu CM*. Docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic activities by decreasing inflammation on prostate cancer cell. Pharmazie. 74(11), 675–679 (2019). (Impact factor:0.82 Ranking: Q4 141/172) (通訊作者)
  30. Chen CY, Kao CL, Liu CM*. The cancer prevention, anti-inflammatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway. Int J Mol Sci. 19(9), 2729 (2018). (Impact factor:3.687 Ranking: Q2 71/205) (通訊作者) 高被引用文章
  31. Liu CM, Kao CL, Tseng YT, Lo YC*, Chen CY*. Ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cell. Molecules. 22(9), 1477 (2017). (Impact factor:2.861 Ranking: N/A) (第一作者)
  32. Wang HM., Kao CL, Liu CM., Li WJ, Yeh HC, Li HT*, Kuo CN*, Chen CY* Chemical constituents of the roots of Pluchea indica. Chem Nat Compd. 53, 736–737 (2017). (Impact factor:0.46 Ranking: Q4 56/59) (第三作者)
  33. Lin CL, Kao CL, Liu CM, Li WJ, Tsai CR, Li CT*, Li HT*, Chen CY*. A new chromone from Citrus reticulata. Chem Nat Compd 52, 789–790 (2016). (Impact factor:0.473 Ranking: Q4 57/59) (第三作者)
  34. Chu CW, Liu CM, Chung MI*, Chen CY*. Biofunctional constituents from Michelia compressa var. lanyuensis with anti-Melanogenic properties. Molecules. 20(7), 12166-12174 (2015). (Impact factor:2.416 Ranking: N/A) (第二作者)
  35. Lo YC, Tseng YT, Liu CM, Wu BN, Wu SN*. Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na+ and Ca2+ -activated K+ currents in GH3 pituitary tumour cells. Br J Pharmacol. 172(21), 5110-5122 (2015). (Impact factor:4.842 Ranking: Q1 24/255) (第三作者)
  36. Kang YF, Liu CM, Kao CL, Chen CY*. Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera. Molecules. 19(4), 4234-4245 (2014). (Impact factor:2.095 Ranking: N/A) (第二作者)
  37. Liu CM, Kao CL, Wu HM, Li WJ, Huang CT*, Li HT*, Chen CY*. Antioxidant and anticancer aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. Molecules. 19(11), 17829-17838 (2014). (Impact factor:2.095 Ranking: N/A) (第一作者)
  38. Liu CM, Fan YC, Lo YC, Wu BN, Yeh JL, Chen IJ *. Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia. Int J Urol. 21(1), 87-92 (2014). (Impact factor:1.91 Ranking: Q2 36/77) (第一作者)
  39. Li HT, Wu HM, Chen HL, Liu CM*, Chen CY*. The pharmacological activities of (-)-anonaine. Molecules. 18(7), 8257-8263 (2013). (Impact factor:2.428 Ranking: N/A) (共同通訊作者) 
  40. Hsu YY, Liu CM, Tsai HH, Jong YJ, Chen IJ, Lo YC*. KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways. Toxicology. 268(1-2), 46-54. (2010) (Impact factor:3.241 Ranking: Q1 19/77) (第二作者)
  41. Liu CM, Lo YC, Tai MH, Wu BN, Wu WJ, Chou YH, Chai CY, Huang CH, Chen IJ*. Piperazine-designed alpha 1A/alpha 1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts. Prostate. 69(6), 610-623. (2009) (Impact factor:3.069 Ranking: Q1 13/57) (第一作者)
  42. Lo YC*, Liu Y, Lin YC, Shih YT, Liu CM, Burka L T. Neuronal effects of 4-t-Butylcatechol: a model for catechol-containing antioxidants. Toxicol Appl Pharmacol. 228(2), 247-255. (2008) (Impact factor:3.846 Ranking: Q1 13/57) (第五作者)
  43. Liu CM, Lo YC, Tai MH, Wu BN, Wu WJ, Chou YH, Huang CH, An LM, Chen IJ*. cGMP-enhancing- and alpha1A/alpha1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy. Prostate. 67(13), 1397-1410. (2007) (Impact factor:3.724 Ranking: Q1 9/55) (第一作者)
  44. Shih YT, Wu DC, Liu CM, Yang YC, Chen IJ, Lo YC*. San-Huang-Xie-Xin-Tang inhibits Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells. J Ethnopharmacol. 112(3), 537-544. (2006) (Impact factor:1.554 Ranking: Q1 1/10) (第三作者)
研討會論文
  • The Multiple Pharmacological Activities of 6-Gingerol Inhibits Cell Growth, Epithelial Mesenchymal Transition, and Drug Resistance Factors in Prostate Cancer. Cells Symposium on World Cancer Research 2024 (SWCR 2024); Apr.22-24, 2024; Singapore (Invited Speaker and Section Chair)
  • Effects of active constituents of ginger inhibit docetaxel resistant prostate cancer through modulating drug resistance factors. International Conference on Traditional Medicine, Phytochemistry, and Medicinal Plants (TMedPM-2018). Oct 15-17, 2018; Narita/Japan (Invited Speaker)
研究計畫
  • 幹細胞在傷口癒合、燒燙傷、過敏性接觸性皮炎作用評估(2024.01-2025.09; 江西佰明醫療健康科技有限公司)
  • 多靶點活性化合物抗良性前列腺增生平台構建 (2018.08-2026.08;宜春學院地方發展研究中心平臺項目)
  • Quinazoline類藥物干擾NGF/TrkA/p75NTR訊息傳遞抑制攝護腺細胞生長(2018.01-2018.12;慈惠醫護管理專科學校)
  • 魚油抑制攝護腺癌細胞之Toll Like Receptor 9訊息傳遞所引起的發炎反應與癌轉移, (2017.01-2017.12;慈惠醫護管理專科學校)
  • 生薑活性萃取物於抗藥性攝護腺癌之開發(2016.01-2016.12;慈惠醫護管理專科學校)
  • 魚油抵抗攝護腺癌細胞之Toll Like Receptor 4訊息傳遞所引起的發炎反應與降低化療藥物的抗性(2015.01-2015.12;慈惠醫護管理專科學校)
榮譽事蹟
  • 2021  第七屆宜春學院互聯網+大學生創新創業大賽 優勝獎 (指導教師;宜春學院)
  • 2021  第七屆全國大學生基礎醫學暨實驗設計論壇分區賽(中南部賽區) 創新研究三等獎 (指導教師;宜春學院)
  • 2022  第八屆宜春學院互聯網+大學生創新創業大賽 優勝獎 (指導教師;宜春學院)
  • 2023  第九屆全國大學生基礎醫學暨實驗設計論壇分區賽(中南部賽區) 創新研究三等獎 (指導教師;宜春學院)
  • 2025  第十一屆全國大學生基礎醫學創新研究暨一帶一路國際競賽基礎臨床賽道中南賽區複賽三等獎 (指導教師;宜春學院)
  • 2020-2021學年  宜春學院優秀教師 
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